Oriental medicine prescription has been used for the treatment of various clinical symptoms associated with cerebral However, single herb drug does not used cerebral apoplexy and there mechanisms of sction have not been apoplexy. defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation.
The study was aimed to investigate the effect Citri Pericarpium (CP) on the vascular systems including changes The changes in rCBF in blood pressure (BP), and regional cerebral blood flow (rCBF) of male Sprague-Dawely rats.
were determinated by laser-Doppler flowmetry
1. Blood pressure was increased by CP in a dose-dependent manner.
2. rCBF was increased by CP in a dose-dependent manner.
3.Pretreatment with propranolol(3mgjkg), methylene blue( Imgjkg), ODQ( 10 ji gjkg) and L-NNA( Imgjkg) was inhibited by CP in a dose-dependent manner in rCBF.
4. Pretreatment with propranolol(3mgjkg), methylene blue( Imgjkg), ODQ( 10 ji gjkg) and L-NNA( Imgjkg) was inhibited
These results suggest that CP causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased in rCBF is also mediated by adrenegic 13 recepter, nitric oxide synthzase and guanylate cyclase.
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